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KMID : 1134819970260050943
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Journal of the Korean Society of Food Science and Nutrition
1997 Volume.26 No. 5 p.943 ~ p.951
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Inhibition Effects of Zanthoxylum schinifolium and Its Active Principle on Lipid Peroxidation and Liver Damage in Carbon Tetrachloride - treated Mice
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Mun Sook-Im
Ryu Hong-Soo
Choi Jae-Sue
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Abstract
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The present study was undertaken to investigate the inhibition effects of sancho(Zanthoxylum schinifolium) on lipid peroxidation and liver damage in carbon tetrachloride-treated mice. Mice aged 3 weeks old were fed diets containing either dry sancho powder, methanol extract or hyperoside isolated from sancho at the various levels for 2 weeks(sancho, methanol extract from sancho) or 3 days (hyperoside) before CCl₄ treatments. Seed coats of sancho added to diet with the levels from 1.25 to 5.0% significantly reduced(p＜0.001) thiobarbituric acid reactive substances(TBARS) formation in liver and serum of mice treated with carbon tetrachloride. CCl₄ treatments significantly increased (p＜0.001) in liver TBARS comparing with those of the untreated control, while methanol extract from the seed coat of sancho added to diet with the levels from 0.5 to 1.0% significantly reduced (p＜0.01) liver TBARS in mice treated with CCl₄, and administration of hyperoside with the levels from 10 to 20㎎ per ㎏ of body weight showed significant reduction(p＜0.01, p＜0.001) of liver TBARS in mice treated with CCl₄ CCl₄ treatments significantly increased(p＜0.05) in serum TBARS comparing with those of the untreated control, while methanol extract from the seed coat of sancho added to diet with the levels from 0.5 to 1.0% significantly reduced(p＜0.01) serum TBARS in mice treated with CCl₄, and administration of hyperoside with the levels from 10 to 20㎎ per ㎏ of body weight showed significant reduction(p＜0.01, p＜0.001) of serum TBARS in mice treated with CCl₄. CCl₄ treatments significantly increased(p＜0.001) in serum AST activities comparing with those of the untreated control, while either addition(0.5, 1.0%) of methanol extract from sancho or administration(10, 20㎎/㎏) of hyperoside significantly reduced(p＜0.001, p＜0.05) serum AST activities in CCl₄-treated mice. CCl₄ treatments showed significant increases(p＜0.001) in serum ALT activities comparing with those of the untreated control, while either addition(0.5, 1.0%) of methanol extract from sancho or administration (10, 20㎎/㎏) of hyperoside showed moderate decreases(p＜0.01, p＜0.001) serum ALT activities in CCl₄-treated mice.
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KEYWORD
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Zanthoxylum schinifolium, hyperoside, TBARS, AST activity, ALT activity
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